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HGH deficiency in children :
When treated with GH, a child lacking will begin to grow faster within months.
Other benefits may be noticed, such as increased strength, progress in motor development, and reduction of body fat.
Side-effects of this type of physiologic replacement are quite rare.
Still, costs of treatment in terms of money, effort, and perhaps quality of life are durable.
Treatment of children usually involves daily injections of growth hormone, usually for as long as the child is growing.
Most pediatric endocrinologists monitor growth and adjust dose every 3–4 months.
Treatment costs vary by country and by size of child, but $US 10,000 to 30,000 a year is common.
Perhaps the most famous person who exemplified the appearance of untreated congenital growth hormone deficiency was Charles Sherwood Stratton (1838–1883), who was exhibited by P. T. Barnum as General Tom Thumb, and married Lavinia Warren.
GH is a protein hormone, like insulin, which had been purified from pig and cow pancreases for treatment of type 1 diabetes since the 1920s.
In the late 1950s, Maurice Raben purified enough GH from human pituitary glands to successfully treat a GH-deficient boy.
Parents would then contract with a biochemist to purify enough growth hormone to treat their child. Few families could manage such a complicated undertaking.